This represents a 25 percent decrease compared with the 6 percent increase predicted by Laplace's law. In other words, in trying to explain why a thicker internal anal sphincter is weaker, we need to emphasize changes in all four variables of Laplace's law. Effects of age on anal function in normal women. Both the thickness and the diameter of the IAS were found to increase significantly with age. That study focused on diameter, wall tension, and anal closure but assumed constant thickness and did not consider the effect of age as a variable. Note the linear relationship between all four variables with their possible effects on anal closure. Laplace's law describes the relationship between the muscle wall thickness, wall tension, and the squeeze pressure generated within a tubular structure, such as the anal canal. To better understand age-related physiologic changes in the IAS of asymptomatic nulliparous females, we compared, in younger and older females, the thickness and diameter of the IAS in MR scans undistorted by the presence of an endoanal probe.
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