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National Library of Medicine. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Hemolytic Disease of the newborn. The most common problem caused by ABO incompatibility is jaundice. For infants whose jaundice is more severe, phototherapy, or light therapy, is effective. Avery's Diseases of the Newborn. Philadelphia, PA: Elsevier Saunders, Some infants with mild jaundice will get better on their own simply by being fed more often. If a baby is type O there won't be a problem with a negative immune response because type O blood cells don't have immune-response triggering antigens.

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